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1

The Medicinal Chemistry of Therapeutic Oligonucleotides

Wan, W. Brad, Seth, Punit P.

Journal:

Journal of Medicinal Chemistry

Année:

2016

Langue:

english

Fichier:

PDF, 1.27 MB

english, 2016

2

Efficient Synthesis and Biological Evaluation of 5′-GalNAc Conjugated Antisense Oligonucleotides

Østergaard, Michael E., Yu, Jinghua, Kinberger, Garth A., Wan, W. Brad, Migawa, Michael T., Vasquez, Guillermo, Schmidt, Karsten, Gaus, Hans J., Murray, Heather M., Low, Audrey, Swayze, Eric E., Praka

Journal:

Bioconjugate Chemistry

Année:

2015

Langue:

english

Fichier:

PDF, 1.33 MB

english, 2015

3

Comprehensive Structure Activity Relationship of Triantennary N -Acetylgalactosamine Conjugated Antisense Oligonucleotides for Targeted Delivery to Hepatocytes

Prakash, Thazha P., Yu, Jinghua, Migawa, Michael T., Kinberger, Garth A., Wan, W. Brad, Østergaard, Michael E, Carty, Recaldo L, Vasquez, Guillermo, Low, Audrey, Chappell, Alfred, Schmidt, Karsten, Ag

Journal:

Journal of Medicinal Chemistry

Année:

2016

Langue:

english

Fichier:

PDF, 1.17 MB

english, 2016

4

Multi-scale habitat selection modeling: a review and outlook

McGarigal, Kevin, Wan, Ho Yi, Zeller, Kathy A., Timm, Brad C., Cushman, Samuel A.

Journal:

Landscape Ecology

Année:

2016

Langue:

english

Fichier:

PDF, 774 KB

english, 2016

5

Synthesis and Spectroscopic Studies of Expanded Planar Dehydrotribenzo[n]annulenes Containing One or Two Isolated Alkene Units

W. Brad Wan, Ryan C. Chiechi, Timothy J. R. Weakley, Michael M. Haley

Journal:

European Journal of Organic Chemistry

Année:

2001

Langue:

english

Fichier:

PDF, 357 KB

english, 2001

6

Synthesis of Expanded Graphdiyne Substructures

W. Brad Wan, Stephen C. Brand, Joshua J. Pak, Michael M. Haley

Journal:

Chemistry - A European Journal

Année:

2000

Langue:

english

Fichier:

PDF, 235 KB

english, 2000

7

ChemInform Abstract: Natural and Non-Natural Planar Carbon Networks: From Monomeric Models to Oligomeric Substructures

Michael M. Haley, W. Brad Wan

Journal:

Année:

2000

Fichier:

PDF, 25 KB

2000

8

ChemInform Abstract: A Versatile Synthetic Route to Dehydrobenzoannulenes via in situ Generation of Reactive Alkynes.

Michael L. Bell, Ryan C. Chiechi, Charles A. Johnson, David B. Kimball, Adam J. Matzger, W. Brad Wan, Timothy J. R. Weakley, Michael M. Haley

Journal:

Année:

2001

Fichier:

PDF, 36 KB

2001

9

ChemInform Abstract: Carbon Networks Based on Dehydrobenzoannulenes. Part 4. Synthesis of “Star” and “Trefoil” Graphdiyne Substructures via Sixfold Cross-Coupling of Hexaiodobenzene.

W. Brad Wan, Michael M. Haley

Journal:

Année:

2001

Fichier:

PDF, 26 KB

2001

10

ChemInform Abstract: Synthesis and Spectroscopic Studies of Expanded Planar Dehydrotribenzo[n]annulenes Containing One or Two Isolated Alkene Units.

W. Brad Wan, Ryan C. Chiechi, Timothy J. R. Weakley, Michael M. Haley

Journal:

Année:

2002

Fichier:

PDF, 35 KB

2002

11

Observation of new vibronic transitions in the B̃2A′'−X̃2A′' manifold of the CH2CHO radical

Ruolian Wan, Xirong Chen, Fei Wu, Brad R. Weiner

Journal:

Chemical Physics Letters

Année:

1996

Langue:

english

Fichier:

PDF, 435 KB

english, 1996

12

A versatile synthetic route to dehydrobenzoannulenes via in situ generation of reactive alkynes

Michael L Bell, Ryan C Chiechi, Charles A Johnson, David B Kimball, Adam J Matzger, W Brad Wan, Timothy J.R Weakley, Michael M Haley

Journal:

Année:

2001

Langue:

english

Fichier:

PDF, 360 KB

english, 2001

13

One-Pot Desilylation/Dimerization of Ethynyl- and Butadiynyltrimethylsilanes. Synthesis of Tetrayne-Linked Dehydrobenzoannulenes.

Michael M Haley, Michael L Bell, Stephen C Brand, David B Kimball, Joshua J Pak, W.Brad Wan

Journal:

Tetrahedron Letters

Année:

1997

Langue:

english

Fichier:

PDF, 492 KB

english, 1997

14

Synthesis of expanded planar dehydrobenzoannulenes: Weakly diatropic, weakly paratropic, or atropic?

W.Brad Wan, David B. Kimball, Michael M. Haley

Journal:

Tetrahedron Letters

Année:

1998

Langue:

english

Fichier:

PDF, 268 KB

english, 1998

15

Pre-gastrula expression of zebrafish extraembryonic genes

Sung-Kook Hong, Carly S Levin, Jamie L Brown, Haiyan Wan, Brad T Sherman, Da Wei Huang, Richard A Lempicki, Benjamin Feldman

Journal:

BMC Developmental Biology

Année:

2010

Langue:

english

Fichier:

PDF, 2.43 MB

english, 2010

16

Effect of oral treatment with (S)-HPMPA, HDP-(S)-HPMPA or ODE-(S)-HPMPA on replication of murine cytomegalovirus (MCMV) or human cytomegalovirus (HCMV) in animal models

Debra C. Quenelle, Deborah J. Collins, Latisha R. Pettway, Caroll B. Hartline, James R. Beadle, W. Brad Wan, Karl Y. Hostetler, Earl R. Kern

Journal:

Antiviral Research

Année:

2008

Langue:

english

Fichier:

PDF, 92 KB

english, 2008

17

Esterification of cidofovir with alkoxyalkanols increases oral bioavailability and diminishes drug accumulation in kidney

Stephanie L Ciesla, Julissa Trahan, W.Brad Wan, James R Beadle, Kathy A Aldern, George R Painter, Karl Y Hostetler

Journal:

Antiviral Research

Année:

2003

Langue:

english

Fichier:

PDF, 157 KB

english, 2003

18

X-ray structure of the ternary MTX·NADPH complex of the anthrax dihydrofolate reductase: A pharmacophore for dual-site inhibitor design

Brad C. Bennett, Qun Wan, Md Faiz Ahmad, Paul Langan, Chris G. Dealwis

Journal:

Journal of Structural Biology

Année:

2009

Langue:

english

Fichier:

PDF, 864 KB

english, 2009

19

O-203 Construction of a DNA microarray with complete coverage of the human genome

Ishkanian, Adrian, Watson, Spencer, Malloff, Chad, Coe, Brad, DeLeeuw, Ronald, Krzywinski, Martin, Marra, Marco, MacAulay, Calum, Lam, Wan

Journal:

Année:

2003

Langue:

english

Fichier:

PDF, 184 KB

english, 2003

20

[American Institute of Aeronautics and Astronautics AIAA Guidance, Navigation, and Control Conference and Exhibit - Austin, Texas ()] AIAA Guidance, Navigation, and Control Conference and Exhibit - Design of Formation Control Laws for Research Aircraft Models

Wan, Sheng, Campa, Giampiero, Napolitano, Marcello, Seanor, Brad, Gu, Y.

Année:

2003

Langue:

english

Fichier:

PDF, 1.21 MB

english, 2003

21

Carbon Networks Based on Dehydrobenzoannulenes. 4. Synthesis of “Star” and “Trefoil” Graphdiyne Substructures via Sixfold Cross-Coupling of Hexaiodobenzene

Wan, W. Brad, Haley, Michael M.

Journal:

Journal of Organic Chemistry

Année:

2001

Langue:

english

Fichier:

PDF, 232 KB

english, 2001

22

Manganese(III)-based asymmetric oxidative free-radical cyclization of unsaturated .beta.-keto sulfoxides

Snider, Barry B., Wan, Barbara Yu Fong, Buckman, Brad O., Foxman, Bruce M.

Journal:

Journal of Organic Chemistry

Année:

1991

Langue:

english

Fichier:

PDF, 998 KB

english, 1991

23

Scanning Gate Spectroscopy and Its Application to Carbon Nanotube Defects

Hunt, Steven R., Wan, Danny, Khalap, Vaikunth R., Corso, Brad L., Collins, Philip G.

Journal:

Année:

2011

Langue:

english

Fichier:

PDF, 4.19 MB

english, 2011

24

Agricultural Pesticide Residues in Farm Ditches of the Lower Fraser Valley, British Columbia, Canada

WAN, MICHAEL, KUO, JEN-NI, McPHERSON, BRAD, PASTERNAK, JOHN

Journal:

Journal of Environmental Science and Health Part B

Année:

2006

Langue:

english

Fichier:

PDF, 541 KB

english, 2006

25

Toward resolving the catalytic mechanism of dihydrofolate reductase using neutron and ultrahigh-resolution X-ray crystallography

Wan, Qun, Bennett, Brad C., Wilson, Mark A., Kovalevsky, Andrey, Langan, Paul, Howell, Elizabeth E., Dealwis, Chris

Journal:

Proceedings of the National Academy of Sciences

Année:

2014

Langue:

english

Fichier:

PDF, 1.09 MB

english, 2014

26

Triazine and Metolachlor Herbicide Residues in Farm Areas of the Lower Fraser Valley, British Columbia, Canada

WAN, MICHAEL, KUO, JEN-NI, MCPHERSON, BRAD, PASTERNAK, JOHN

Journal:

Journal of Environmental Science and Health Part B

Année:

2006

Langue:

english

Fichier:

PDF, 230 KB

english, 2006

27

[IEEE 2010 Ninth IEEE Sensors Conference (SENSORS 2010) - Kona, HI (2010.11.1-2010.11.4)] 2010 IEEE Sensors - Sensitivity of point defects in one dimensional nanocircuits

Hunt, Steven R, Hoang, Phuc D, Khalap, Vaikunth R, Wan, Danny, Corso, Brad L, Collins, Philip G

Année:

2010

Langue:

english

Fichier:

PDF, 1.41 MB

english, 2010

28

Synthesis And Characterization Of Fluorinated Poly(Arylethers): Organic Polymers For Ic Imd

Hendricks, Neil H., Lau, Kreisler S. Y., Smith, Aaron R., Wan, W. Brad

Journal:

MRS Proceedings

Année:

1995

Langue:

english

Fichier:

PDF, 1.90 MB

english, 1995

29

Oral Activity of Ether Lipid Ester Prodrugs of Cidofovir against Experimental Human Cytomegalovirus Infection

Bidanset, Deborah J., Beadle, James R., Wan, W. Brad, Hostetler, Karl Y., Kern, Earl R.

Journal:

The Journal of Infectious Diseases

Année:

2004

Langue:

english

Fichier:

PDF, 137 KB

english, 2004

30

Preliminary joint X-ray and neutron protein crystallographic studies of ecDHFR complexed with folate and NADP +

Wan, Qun, Kovalevsky, Andrey Y., Wilson, Mark A., Bennett, Brad C., Langan, Paul, Dealwis, Chris

Journal:

Acta Crystallographica Section F Structural Biology Communications

Année:

2014

Langue:

english

Fichier:

PDF, 459 KB

english, 2014

31

S33 Suppression of constitutive and stimulated secretion of histamine from human lung mast cells by a secreted factor from lung epithelial cells

Martin, N., Arthur, G. K., Wan, W. Y. H., Woodman, L., Brightling, C. E., Pavord, I. D., Bradding, P.

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 95 KB

english, 2010

32

Solid-phase synthesis of 5′-triantennary N-acetylgalactosamine conjugated antisense oligonucleotides using phosphoramidite chemistry

T. P. Prakash, W. Brad Wan, A. Low, J. Yu, A. E. Chappell, H. Gaus, G. A. Kinberger, M. E. Østergaard, M. T. Migawa, E. E. Swayze, P. P. Seth

Année:

2015

Langue:

english

Fichier:

PDF, 563 KB

english, 2015

33

A convenient synthesis of 5′-triantennary N-acetyl-galactosamine clusters based on nitromethanetrispropionic acid

Migawa, Michael T., Prakash, Thazha P., Vasquez, Guillermo, Wan, W. Brad, Yu, Jinghua, Kinberger, Garth A., Østergaard, Michael E., Swayze, Eric E., Seth, Punit P.

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2016

Langue:

english

Fichier:

PDF, 692 KB

english, 2016

34

FGF-18, a Novel Member of the Fibroblast Growth Factor Family, Stimulates Hepatic and Intestinal Proliferation

Hu, Mickey C.-T., Qiu, Wan R., Wang, You-ping, Hill, Dave, Ring, Brian D., Scully, Sheila, Bolon, Brad, DeRose, Margaret, Luethy, Roland, Simonet, W. Scott, Arakawa, Tsutomu, Danilenko, Dimitry M.

Journal:

Molecular and Cellular Biology

Année:

1998

Langue:

english

Fichier:

PDF, 2.81 MB

english, 1998

35

Multi-analyte Biochip (MAB) Based on All-solid-state Ion-selective Electrodes (ASSISE) for Physiological Research

Wan Salim, Wan W. Amani, Zeitchek, Michael A., Hermann, Andrew C., Ricco, Antonio J., Tan, Ming, Selch, Florian, Fleming, Erich, Bebout, Brad M., Bader, Mamoun M., ul Haque, Aeraj, Porterfield, D. Mar

Journal:

Journal of Visualized Experiments

Année:

2013

Langue:

english

Fichier:

PDF, 417 KB

english, 2013

36

Detection of Antigenic Variants of Subtype H3 Swine Influenza A Viruses from Clinical Samples

Martin, Brigitte E., Bowman, Andrew S., Li, Lei, Nolting, Jacqueline M., Smith, David R., Hanson, Larry A., Wan, Xiu-Feng, Fenwick, Brad

Journal:

Journal of Clinical Microbiology

Année:

2017

Langue:

english

Fichier:

PDF, 2.93 MB

english, 2017

37

Meta-replication reveals nonstationarity in multi-scale habitat selection of Mexican Spotted Owl

Wan, Ho Yi, McGarigal, Kevin, Ganey, Joseph L., Lauret, Valentin, Timm, Brad C., Cushman, Samuel A.

Journal:

Année:

2017

Langue:

english

Fichier:

PDF, 2.60 MB

english, 2017

38

Endosomal Escape of ASOs Internalized by Stabilin Receptors Is Regulated by Rab5C and EEA1 During Endosomal Maturation

Miller, Colton M., Wan, W. Brad, Seth, Punit P., Harris, Edward N.

Journal:

Nucleic Acid Therapeutics (Formerly Oligonucleotides)

Année:

2018

Langue:

english

Fichier:

PDF, 625 KB

english, 2018

39

Uncertainty Quantification in Alchemical Free Energy Methods

Bhati, Agastya P., Wan, Shunzhou, Hu, Yuan, Sherborne, Brad, Coveney, Peter Vivian

Journal:

Journal of Chemical Theory and Computation

Année:

2018

Langue:

english

Fichier:

PDF, 3.17 MB

english, 2018

40

Histidine Hydrogen-Deuterium Exchange Mass Spectrometry for Probing the Microenvironment of Histidine Residues in Dihydrofolate Reductase

Miyagi, Masaru, Wan, Qun, Ahmad, Md. Faiz, Gokulrangan, Giridharan, Tomechko, Sara E., Bennett, Brad, Dealwis, Chris, Croft, Anna

Journal:

Année:

2011

Langue:

english

Fichier:

PDF, 1.18 MB

english, 2011

41

Primary Human Airway Epithelial Cell-Dependent Inhibition of Human Lung Mast Cell Degranulation

Martin, Neil, Ruddick, Andrew, Arthur, Greer K., Wan, Heidi, Woodman, Lucy, Brightling, Christopher E., Jones, Don J. L., Pavord, Ian D., Bradding, Peter, Thatcher, Thomas H.

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 455 KB

english, 2012

42

Modeling and prediction of modulus of elasticity of laminated veneer lumber based on laminated plate theory

Wei, Peixing, Wang, Brad Jianhe, Wan, Xiaojun, Chen, Xiaohan

Journal:

Construction and Building Materials

Année:

2019

Fichier:

PDF, 1.13 MB

2019

43

Site-specific replacement of phosphorothioate with alkyl phosphonate linkages enhances the therapeutic profile of gapmer ASOs by modulating interactions with cellular proteins

Migawa, Michael T, Shen, Wen, Wan, W Brad, Vasquez, Guillermo, Oestergaard, Michael E, Low, Audrey, De Hoyos, Cheryl L, Gupta, Ruchi, Murray, Susan, Tanowitz, Michael, Bell, Melanie, Nichols, Joshua G

Journal:

Nucleic Acids Research

Année:

2019

Langue:

english

Fichier:

PDF, 7.90 MB

english, 2019